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In a study in adults, there was no difference between prilocaine and articaine in providing successful anesthesia of mandibular pulpal and lingual soft tissue and of maxillary palatal soft tissue with buccal infiltration. Together with the lidocaine-prilocaine 1:1 mixture, the poloxamers form a low-viscosity fluid system at room temperature and an elastic gel in the periodontal pocket. Prilocaine is chemically designated as N-(2-methylphenyl)-2 (propylamino)-propanamide and has an octanol:water partition ratio of 25 at pH 7. lidocaine and prilocaine can cause serious side effects, especially in children, if any of it gets into the mouth or is swallowed. The prilocaine metabolite o-toluidine and the hydroxylated metabolites of o-toluidine are excreted mainly in the urine. lidocaine and prilocaine helps prevent pain, but it will not calm a frightened child.
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