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Comparison of articaine and prilocaine anesthesia by infiltration in maxillary and mandibular arches. 6 times the MRHD) {06} {12} {23}, or prilocaine (using 30 times the MRHD) have not shown adverse effects on the fetus {38}. If you have not received other instructions about how to apply lidocaine and prilocaine, follow the patient directions that come with the medicine. The prilocaine metabolite o-toluidine and the hydroxylated metabolites of o-toluidine are excreted mainly in the urine. When administered intravenously, the mean volume of distribution (for 60-kg person) at steady state for lidocaine and prilocaine were 90 L and 156 L, respectively.

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